USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: AAC1_HUMAN USC-OGP 2-DE database:  AAC1_HUMAN AAC1_HUMAN General information about the entry View entry in simple text format Entry name AAC1_HUMAN Primary accession number P12814 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Alpha-actinin-1; AltName: Full=Alpha-actinin cytoskeletal isoform; AltName: Full=F-actin cross-linking protein; AltName: Full=Non-muscle alpha-actinin-1;. Gene name Name=ACTN1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0042: pI=5.01; Mw=59800 SPOT OGP-0076: pI=4.86; Mw=49615 SPOT OGP-0128: pI=5.00; Mw=34710 SPOT OGP-0175: pI=4.61; Mw=27318 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0276: pI=5.41; Mw=119336 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1101: pI=5.44; Mw=126814 Cross-references UniProtKB/Swiss-Prot P12814; ACTN1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ACTN1_HUMAN Primary accession number P12814 Secondary accession number(s) B3V8S3 B4DHH3 B7TY16 Q1HE25 Q9BTN1 Sequence was last modified on  April 13, 2004 (version 2) Annotations were last modified on  March 15, 2017 (version 207) Name and origin of the protein Description RecName: Full=Alpha-actinin-1; AltName: Full=Alpha-actinin cytoskeletal isoform; AltName: Full=F-actin cross-linking protein; AltName: Full=Non-muscle alpha-actinin-1; Gene name Name=ACTN1 Encoded on Name=ACTN1 Keywords 3D-structure; Acetylation; Actin-binding; Alternative splicing; Calcium; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X15804; CAA33803.1; -; mRNA EMBL M95178; AAA51582.1; -; mRNA EMBL EU716325; ACE62922.1; -; mRNA EMBL DQ496098; ABF50047.1; -; mRNA EMBL FJ410030; ACJ24535.1; -; mRNA EMBL BT007207; AAP35871.1; -; mRNA EMBL AK295099; BAG58135.1; -; mRNA EMBL AL117694; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471061; EAW80975.1; -; Genomic_DNA EMBL BC003576; AAH03576.1; -; mRNA EMBL BC015766; AAH15766.1; -; mRNA EMBL X55187; CAA38970.1; -; mRNA CCDS CCDS45129.1; -. [P12814-2]; . CCDS CCDS45130.1; -. [P12814-3]; . CCDS CCDS9792.1; -. [P12814-1]; . PIR S05503; FAHUAA; . RefSeq NP_001093.1; NM_001102.3. [P12814-1]; . RefSeq NP_001123476.1; NM_001130004.1. [P12814-3]; . RefSeq NP_001123477.1; NM_001130005.1. [P12814-2]; . UniGene Hs.235750; -; . UniGene Hs.509765; -; . PDB 2EYI; X-ray; 1.70 A; A=30-253 PDB 2EYN; X-ray; 1.80 A; A=30-253 PDB 2N8Y; NMR; -; A=743-892 PDB 2N8Z; NMR; -; A=743-892 PDBsum 2EYI; -; . PDBsum 2EYN; -; . PDBsum 2N8Y; -; . PDBsum 2N8Z; -; . ProteinModelPortal P12814; -; . SMR P12814; -; . BioGrid 106602; 126; . DIP DIP-33184N; -; . IntAct P12814; 82; . MINT MINT-215335; -; . STRING 9606.ENSP00000377941; -; . iPTMnet P12814; -; . PhosphoSitePlus P12814; -; . SwissPalm P12814; -; . BioMuta ACTN1; -; . DMDM 46397817; -; . OGP P12814; -; . EPD P12814; -; . MaxQB P12814; -; . PaxDb P12814; -; . PeptideAtlas P12814; -; . PRIDE P12814; -; . DNASU 87; -; . Ensembl ENST00000193403; ENSP00000193403; ENSG00000072110. [P12814-1]; . Ensembl ENST00000394419; ENSP00000377941; ENSG00000072110. [P12814-3]; . Ensembl ENST00000438964; ENSP00000414272; ENSG00000072110. [P12814-2]; . Ensembl ENST00000538545; ENSP00000439828; ENSG00000072110. [P12814-4]; . GeneID 87; -; . KEGG hsa:87; -; . UCSC uc001xkl.4; human. [P12814-1]; . CTD 87; -; . DisGeNET 87; -; . GeneCards ACTN1; -; . HGNC HGNC:163; ACTN1; . HPA CAB004303; -; . HPA HPA006035; -; . MalaCards ACTN1; -; . MIM 102575; gene; . MIM 615193; phenotype; . neXtProt NX_P12814; -; . OpenTargets ENSG00000072110; -; . Orphanet 140957; Autosomal dominant macrothrombocytopenia; . PharmGKB PA24; -; . eggNOG KOG0035; Eukaryota; . eggNOG COG5069; LUCA; . GeneTree ENSGT00760000118813; -; . HOGENOM HOG000263418; -; . HOVERGEN HBG050453; -; . InParanoid P12814; -; . KO K05699; -; . OMA NDMTRKW; -; . OrthoDB EOG091G020R; -; . PhylomeDB P12814; -; . TreeFam TF352676; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-3000170; Syndecan interactions; . Reactome R-HSA-373753; Nephrin interactions; . Reactome R-HSA-446388; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components; . SIGNOR P12814; -; . ChiTaRS ACTN1; human; . EvolutionaryTrace P12814; -; . GeneWiki Actinin; _alpha_1; -; . GenomeRNAi 87; -; . PRO PR:P12814; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000072110; -; . CleanEx HS_ACTN1; -; . ExpressionAtlas P12814; baseline and differential; . Genevisible P12814; HS; . GO GO:0005903; C:brush border; IEA:Ensembl; . GO GO:0042995; C:cell projection; IDA:UniProtKB; . GO GO:0005911; C:cell-cell junction; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005916; C:fascia adherens; IEA:Ensembl; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0005622; C:intracellular; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0031143; C:pseudopodium; TAS:UniProtKB; . GO GO:0001726; C:ruffle; IDA:UniProtKB; . GO GO:0001725; C:stress fiber; IDA:UniProtKB; . GO GO:0030018; C:Z disc; IEA:UniProtKB-SubCell; . GO GO:0051015; F:actin filament binding; IDA:UniProtKB; . GO GO:0005509; F:calcium ion binding; IEA:InterPro; . GO GO:0003725; F:double-stranded RNA binding; IDA:MGI; . GO GO:0005178; F:integrin binding; IDA:UniProtKB; . GO GO:0044325; F:ion channel binding; IPI:UniProtKB; . GO GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:UniProtKB; . GO GO:0042803; F:protein homodimerization activity; IDA:UniProtKB; . GO GO:0017166; F:vinculin binding; IDA:UniProtKB; . GO GO:0051764; P:actin crosslink formation; IEA:InterPro; . GO GO:0051017; P:actin filament bundle assembly; IEA:Ensembl; . GO GO:0051639; P:actin filament network formation; IMP:UniProtKB; . GO GO:0007015; P:actin filament organization; IMP:UniProtKB; . GO GO:0048041; P:focal adhesion assembly; IMP:UniProtKB; . GO GO:0051271; P:negative regulation of cellular component movement; IMP:UniProtKB; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0030220; P:platelet formation; IMP:UniProtKB; . GO GO:0036344; P:platelet morphogenesis; IMP:UniProtKB; . GO GO:0042981; P:regulation of apoptotic process; NAS:UniProtKB; . CDD cd00014; CH; 2; . CDD cd00051; EFh; 1; . Gene3D 1.10.238.10; -; 2; . Gene3D 1.10.418.10; -; 2; . InterPro IPR001589; Actinin_actin-bd_CS; . InterPro IPR026921; Alpha-actinin_1; . InterPro IPR001715; CH-domain; . InterPro IPR011992; EF-hand-dom_pair; . InterPro IPR014837; EF-hand_Ca_insen; . InterPro IPR018247; EF_Hand_1_Ca_BS; . InterPro IPR002048; EF_hand_dom; . InterPro IPR018159; Spectrin/alpha-actinin; . InterPro IPR002017; Spectrin_repeat; . PANTHER PTHR11915:SF399; PTHR11915:SF399; 1; . Pfam PF00307; CH; 2; . Pfam PF08726; EFhand_Ca_insen; 1; . Pfam PF00435; Spectrin; 4; . SMART SM00033; CH; 2; . SMART SM00054; EFh; 2; . SMART SM00150; SPEC; 3; . SUPFAM SSF47473; SSF47473; 1; . SUPFAM SSF47576; SSF47576; 1; . PROSITE PS00019; ACTININ_1; 1; . PROSITE PS00020; ACTININ_2; 1; . PROSITE PS50021; CH; 2; . PROSITE PS00018; EF_HAND_1; 1; . PROSITE PS50222; EF_HAND_2; 2; .

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